Jakobsson Lab

Contact Info

Mattias Jakobsson

mattias.jakobsson[at]ebc.uu.se

+46 (0)18-471 6449 (office)
+46 (0)18-471 6310 (fax)

Mailing address:

Dept. of Evolutionary biology, EBC,
Uppsala University,
Norbyägen 18D,
75236 Uppsala, Sweden

Visiting address:

EBC, Norbyvägen 18D, Room 1035
 

Mattias Jakobsson Lab

News: April 26 -- Our paper was published in Science -- see News and Events

 

Lab
From left: Sen Li, Patrik Båtelsson, Agnes Sjöstrand, Mattias Jakobsson, Per Sjödin, Hiba Babiker, Carina Schlebusch, Lucie Gattepaille, and Pontus Skoglund. (New members not in photo: Solenn Stoeckel and Katie Owers)

 

 

 

Mattias Jakobsson 

Mattias Jakobsson

Assistant Professor

We are associated with:

Department of Evolutionary Biology
Evolutionary Biology Centre (EBC)
EBC Graduate School on Genomes and Phenotypes
SciLifeLab Uppsala

Research interests

The research focuses on understanding evolutionary and demographic processes by using mathematical models and developing and utilizing statistical and computational methods for analyzing large genomic data sets. Specifically, we are interested in:

  • Human evolutionary genetics and inferring demographic history based population-genetic data.
  • Theoretical population genetics.
  • Developing methods for searching for genes targeted by recent selection.
  • Models of founder events and their implications for patterns of genetic variation.
  • The impact of demography on gene-mapping.

Background

2005-2008: Postdoc, Computational biology, Rosenberg Lab, University of Michigan.
2005: PhD, Genetics, Section for Evolutionary Genetics, Lund University.
2003-2004: Research visit at the Nordborg Lab, University of Southern California.
2001: MS Biology and Mathematics, Lund University.

Our research is funded by:

Vetenskapsrådet

STINT FORMAS

Selected publications

  • P Skoglund, H Malmström, M Raghavan, J Storå, P Hall, E Willerslev, MTP Gilbert, A Götherström & M Jakobsson. (2012) Origins and Genetic Legacy of Neolithic Farmers and Hunter-Gatherers in Europe. Science, 336: 466-469.
  • LM Gattepaille & M Jakobsson. (2012) Combining markers into haplotypes can improve population structure inference. Genetics, 190: 159-174.
  • P Skoglund & M Jakobsson. (2011) Archaic human ancestry in East Asia. Proceedings of the National Academy of Sciences USA, 108: 18301-18306.
  • P Skoglund, A Götherström & M Jakobsson. (2011) Estimation of population divergence times from non-overlapping genomic sequences: examples from dogs and wolves. Molecular Biology and Evolution, 28: 1505-1517

  •  MGB Blum & M Jakobsson (2011) Deep divergences of human gene trees and models of human origins. Molecular Biology and Evolution. 28: 889-898.

  • M Jakobsson (2009) COMPASS: A program for generating serial samples under an infinite sites model. Bioinformatics, 25: 2845-2847.

  • M DeGiorgio, M Jakobsson & NA Rosenberg (2009) Explaining worldwide patterns of human genetic variation using a coalescent-based serial founder model of migration outward from Africa. Proceedings of the National Academy of Sciences USA, 106: 16057-16062.

  • M Jakobsson*, SW Scholz*, P Scheet*, JR Gibbs, JM VanLiere, H-C Fung, ZA Szpiech, JH Degnan, K Wang, R Guerreiro, JM Bras, JC Schymick, D Hernandez, BJ Traynor, J Simon-Sanchez, Matarin, M., A Britton, J van de Leemput, I Rafferty, M Bucan, HM Cann, JA Hardy, NA Rosenberg, & AB Singleton, (2008) Genotype, haplotype, and copy number variation in worldwide human populations. Nature, 451: 998-1003.
  • M Jakobsson & NA Rosenberg (2007) CLUMPP: a cluster matching and permutation program for dealing with label switching and multimodality in analysis of population structure. Bioinformatics 23: 1801-1806.