Cecilia Berg
Associate professor
Department of Environmental Toxicology
Uppsala University
Norbyvägen 18A
SE-752 36 Uppsala
Sweden
Phone: +46 18 471 2621
Fax: +46 18 51 88 43
E-mail: cecilia.berg@ebc.uu.se
Since 2007 I hold an associate professorship in environmental toxicology. I am interested in sex differentiation and reproductive system development and how these processes are affected by exposure to chemicals. Transient exposure to chemicals during critical periods of embryo-foetal development can result in reproductive disorders and impaired fertility as the animal become adult. Using the frog as a model we investigate endocrine disruption, developmental and reproductive toxicity using methods that range over several levels of biological organisation including molecular, physiological, and behavioural.
Persons:
Staff presently involved:
PhD student Moa Säfholm, Dr Anna Mattsson, Dr. Jan Olsson, Professor Ingvar Brandt, technical assistants Anna Norder and Erika Jansson, and MSc student Nicolas Mathieu.
Former members of the group:
PhD student: Irina Gyllenhammar (PhD 2008).
Master students: Johanna Tyselius, Eva-Maria Staaf, Rosita Eklund, Hanna Eriksson, Anneli Söderqvist, Melle Andersson.
I am involved in the following projects at the department:
Publications (peer-reviewed)
Säfholm M, Norder, A, Fick J, Berg, C. (2011) Disrupted Oogenesis in the Frog Xenopus tropicalis After Exposure to Environmental Progestin Concentrations.Biol Reprod. 2011 Dec 21. Epub ahead of print. DOI:10.1095/biolreprod.111.097378
Kvarnryd, M., Grabic, R., Brandt, I., Berg, C. (2011) Early life progestin exposure causes arrested oocyte development, oviductal agenesis and sterility in adult Xenopus tropicalis frogs, Aquat Toxicol, 103:18–24. PubMed link
Jönsson M, Berg C, Goldstone J, Stegeman J. (2011) New CYP1 genes in the frog Xenopus (Silurana) tropicalis: Induction patterns and effects of AHR agonists during development. Toxicology and Applied Pharmacology 250(2):170-83. doi link
Berg C, Gyllenhammar I and Kvarnryd M (2009) Xenopus tropicalis as a test system for developmental and reproductive toxicity. J Toxicol Environ Health A. 72: 219-225. PubMed link
Brunelli E, Bernabò I, Berg C, Lundstedt-Enkel K, Bonacci A and Tripepi S (2009) Environmentally relevant concentrations of endosulfan impair development, metamorphosis and behaviour in Bufo bufo tadpoles. Aquat Toxicol. 91: 135-142. PubMed link
Gyllenhammar I, Eriksson H, Söderqvist A, Lindberg RH, Fick J and Berg C (2009) Clotrimazole exposure modulates aromatase activity in gonads and brain during gonadal differentiation in Xenopus tropicalis frogs. Aquat Toxicol. 91: 102-109. PubMed link
Gyllenhammar I, Holm L, Eklund R and Berg C (2009) Reproductive toxicity in Xenopus tropicalis after developmental exposure to environmental concentrations of ethynylestradiol. Aquat Toxicol. 91: 171-178. PubMed link
Karlsson O, Berg C, Brittebo EB and Lindquist NG (2009) Retention of the cyanobacterial neurotoxin beta-N-methylamino-l-alanine in melanin and neuromelanin-containing cells--a possible link between Parkinson-dementia complex and pigmentary retinopathy. Pigment Cell Melanoma Res. 22: 120-130. PubMed link
Bernabò I, Brunelli E, Berg C, Bonacci A and Tripepi S (2008) Endosulfan acute toxicity in Bufo bufo gills: Ultrastructural changes and nitric oxide synthase localization. Aquat Toxicol. 86: 447-456. PubMed link
Pettersson I and Berg C (2007) Environmentally relevant concentrations of ethynylestradiol cause female-biased sex ratios in Xenopus tropicalis and Rana temporaria. Environ Toxicol Chem. 26: 1005-1009. PubMed link
Blomqvist A, Berg C, Holm L, Brandt I, Ridderstråle Y and Brunström B (2006) Defective Reproductive Organ Morphology and Function in Domestic Rooster Embryonically Exposed to o,p'-DDT or Ethynylestradiol. Biol Reprod. 74: 481-486.
Holm L, Blomqvist A, Brandt I, Brunström B, Ridderstråle Y and Berg C (2006) Embryonic exposure to o,p'-DDT causes eggshell thinning and altered shell gland carbonic anhydrase expression in the domestic hen. Environ Toxicol Chem. 25: 2787-2793.
Pettersson I, Arukwe A, Lundstedt-Enkel K, Mortensen AS and Berg C (2006) Persistent sex-reversal and oviducal agenesis in adult Xenopus (Silurana) tropicalis frogs following larval exposure to the environmental pollutant ethynylestradiol. Aquat Toxicol. 79: 356-365.
Berg C, Blomqvist A, Holm L, Brandt I, Brunström B and Ridderstråle Y (2004) Embryonic exposure to oestrogen causes eggshell thinning and altered shell gland carbonic anhydrase expression in the domestic hen. Reproduction. 128: 455-461.
Berg C, Halldin K and Brunström B (2001) Effects of bisphenol A and tetrabromobisphenol A on sex organ development in quail and chicken embryos. Environ Toxicol Chem. 20: 2836-2840.
Berg C, Holm L, Brandt I and Brunström B (2001) Anatomical and Histological Changes in the Oviducts of Japanese Quail after Embryonic Exposure to Ethynyloestradiol. Reproduction. 121: 155-165.
Halldin K, Berg C, Bergman Å, Brandt I and Brunström B (2001) Distribution of bisphenol A and tetrabromobisphenol A in quail eggs, embryos and laying birds and studies on reproduction variables in adults following in ovo exposure. Arch Toxicol. 75: 597-603.
Holm L, Berg C, Brunström B, Ridderstråle Y and Brandt I (2001) Disrupted carbonic anhydrase distribution in the avian shell gland following in ovo exposure to estrogen. Arch Toxicol. 75: 362-368.
Berg C (2000) Environmental Pollutants and the Reproductive System in Birds: Developmental effects of Estrogenic compounds. Doctoral thesis. Department of Environmental Toxicology. Uppsala University.
Berg C, Halldin K, Fridolfsson AK, Brandt I and Brunström B (1999) The Avian Egg as a Test System for Endocrine Disrupters: Effects of diethylstilbestrol and ethynylestradiol on sex organ development. Science of the Total Environment. 233: 57-66.
Halldin K, Berg C, Brandt I and Brunström B (1999) Sexual behavior in Japanese quail as a test end point for endocrine disruption: effects of in ovo exposure to ethinylestradiol and diethylstilbestrol. Environ Health Perspect. 107: 861-866.
Berg C, Halldin K, Brunström B and Brandt I (1998) Methods for studying xenoestrogenic effects in birds. Toxicol Lett. 102-103: 671-676.
Brandt I, Berg C, Halldin K and Brunström B (1998) Developmental and reproductive toxicity of persistent environmental pollutants. Arch Toxicol Suppl. 20: 111-119.
Other publications
Berg C (2003) Frogs are more sensitive than we think. Swedish Research for Sustainability. No 2/03. Formas, the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning.
Berg C (2003) Grodor känsligare än vi tror. Miljöforskning. Nr 3/03. Formas, forskningsrådet för miljö, areella näringar och samhällsbyggande.
